Ibuprofen has been shown to increase the likelihood of stomach ulcers because it thins the protective mucous lining of your stomach. You and your doctor should be aware of how much ibuprofen you are taking to minimize any chance of stomach ulcers. In addition, steroids, such as prednisone, decrease the normal absorption of calcium and increase the excretion of calcium. Therefore, most women on steroids should also be supplementing their diet with calcium and vitamin D.